With that said, pharmaceuticals have come a long way, you can lobotomize someone with a pill these days, there could be chemical compounds we have no knowledge of.
And if you are a wealthy person and you dont want someone talking about something, you can turn them into a drug addict, destroy their brain, turn them schizophrenic, lead them to a drug overdose. I'm sure a lot of people have been murdered that way to be silenced.

In the modern age, the government/elites/satanist/whatever doesnt need to artificially induce dissociative states with spooky rape rituals to create a sex slave, they can simply medicate a person into a highly suggestible state, or cover up crimes by turning people into crack heads that no one will believe after theyre done with them.