I wouldn't but I've been thinking about making a game starring my favorite anime girls. I'm thinking 2.5D (3D gameplay, 2D sprite graphics, like in Duke Nukem 3D) would be best because anime girls look best in 2D. MMD videos never look as good as 2D animation. I'm thinking of making it first-person and the player character will be a nameless faceless guy that you never see other than his hands and PENIS which you will pretend are your hands and PENIS.